Article ID Journal Published Year Pages File Type
1345014 Tetrahedron: Asymmetry 2008 4 Pages PDF
Abstract
The synthesis of a fully deprotected ketimine-type iminosugar is reported, starting from commercial d-mannose diacetonide. An appropriate solvent system was critical for the success of the key tandem addition/cyclization reaction. Reduction of the imine was also achieved to yield the corresponding pyrrolidine in a stereoselective manner. The cyclic sugar imine displayed modest fucosidase inhibitory activity when compared to the saturated analogue.
Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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