| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1345265 | Tetrahedron: Asymmetry | 2007 | 13 Pages |
Abstract
The stereochemistry of H-phosphonate diester bond formation (including internucleotide ones) with ribonucleoside H-phosphonates as substrates has been investigated using 31P NMR spectroscopy. It was found that the reactions investigated owe their stereoselectivity to a dynamic kinetic asymmetric transformation. The absolute configurations of the compounds involved in the reaction pathways were tentatively assigned on the basis of their 31P NMR chemical shifts and their correctness was verified for the H-phosphonic–pivalic mixed anhydrides and H-phosphonate aryl esters.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Michal Sobkowski, Adam Kraszewski, Jacek Stawinski,