Recent advances in the application of the Oppolzer camphorsultam as a chiral auxiliary

Oppolzer’s camphorsultam has attracted much attention as an efficient chiral auxiliary, and is one of the most powerful synthetic tools in asymmetric synthesis. The sultam chiral auxiliary can be applied in a variety of different reactions such as alkylations, allylations, 1,3-dipolar cycloadditions, cyclopropanation, reductions, Diels–Alder, aldol and ene reactions. These applications have been highly successful in the stereoselective construction of a number of important natural products via total synthesis. The present review is focused on the utility and versatility of the sultam in various asymmetric reactions.

Graphical abstractIn this review, the applications of sultam as achiral auxiliary in various asymmetric reactions such as alkylation, allylation, 1,3-dipolar cycloaddition, cyclopropanation, reduction, Diels–Alder, aldol, and ene reaction are described.Figure optionsDownload full-size imageDownload as PowerPoint slide