The conjugate addition of enantiomerically pure lithium amides as chiral ammonia equivalents part II: 2005−2011

We published a review concerning the scope and application of the conjugate addition of enantiomerically pure lithium amides in 2005. This review comprehensively updates recent developments of this reaction, all the new reports of this methodology, and its applications in synthesis since the publication of our first review up to the end of 2011.

Graphical abstractThis review comprehensively updates recent developments, all the new reports and the applications of the highly diastereoselective conjugate addition of an enantiomerically pure lithium amide to an α,β-unsaturated carbonyl compound.Figure optionsDownload full-size imageDownload as PowerPoint slide