| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346020 | Tetrahedron: Asymmetry | 2005 | 7 Pages |
The four diastereoisomers of 1-fluoro-2-amino-indane have been synthesized in high enantiomeric excess with lipase resolution of cis-2-azido-1-indanol as a key step.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
(1S,2R)-1-Fluoro-2-amino-indane hydrochloride saltC9ClH11NEe = 99%[α]D20=+18.3 (c 0.34, MeOH)Source of chirality: enzymatic resolutionAbsolute configuration: (1S,2R)
(1R,2S)-1-Fluoro-2-amino-indane hydrochloride saltC9ClH11NEe = 99%[α]D20=-18.6 (c 0.47, MeOH)Source of chirality: enzymatic resolutionAbsolute configuration: (1R,2S)
(1R,2R)-1-Fluoro-2-amino-indane hydrochloride saltC9ClH11NEe = 99%[α]D20=+19.3 (c 1, MeOH)Source of chirality: enzymatic resolutionAbsolute configuration: (1R,2R)
(1S,2S)-1-Fluoro-2-amino-indane hydrochloride saltC9ClH11NEe = 99%[α]D20=-19.5 (c 1, MeOH)Source of chirality: enzymatic resolutionAbsolute configuration: (1S,2S)
