| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346045 | Tetrahedron: Asymmetry | 2014 | 17 Pages |
Isoretronecanol and trachelantamidine (laburnine) are naturally occurring pyrrolizidine alkaloids which display potent biological activity, and as such these compounds have, in recent years, attracted significant interest from the bioorganic and synthetic communities. This review delineates both the asymmetric and enantiospecific syntheses of 1-hydroxymethyl pyrrolizidine alkaloids including isoretronecanol, trachelantamidine (laburnine) and related hydroxylated compounds.
Graphical abstractA review of the asymmetric syntheses of important 1-hydroxymethyl pyrrolizidine alkaloids, such as isoretronecanol, trachelantamidine (laburnine) and related hydroxylated compounds, is presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
