Asymmetric Baylis–Hillman reactions using (R)-4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl) benzoic acid acrylate derivatives in solution and on solid support

The influence of several variables on the course of the Baylis–Hillman reaction between the (R)-4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl) benzoic acid acrylate derivatives (R)-2 and (R)-3 and aromatic aldehydes has been investigated both in solution and on solid support: these resulted in comparable results with the formation of adducts in high yield and moderate selectivity.

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