| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346197 | Tetrahedron: Asymmetry | 2013 | 7 Pages |
Abstract
The asymmetric reductive amination of aryl-ketones bearing various boron-functionalities (acid, ester or potassium trifluoroborates) was investigated employing enantiocomplementary ω-transaminases as catalysts. Under the optimized conditions, high conversions (up to 94%) and excellent ee’s (up to >99%) were obtained providing access to both (R)- and (S)-configured amino-aryl boronates under mild reaction conditions.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Joel S. Reis, Robert C. Simon, Wolfgang Kroutil, Leandro H. Andrade,