| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346656 | Tetrahedron: Asymmetry | 2010 | 4 Pages |
Abstract
A new synthesis of harzialactone A together with its stereoisomers was achieved starting from phenyl acetone. The key step of this new route is the kinetic bioresolution of racemic cis- and trans-isomers by recombinant Escherichia coli JM109 cells expressing Fusarium proliferatum lactonase gene (reFPL). Harzialactone A was isolated in excellent ee (>99%), while moderate to good enantioselectivities (80% to >99% ee) were obtained for its isomers.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Bing Chen, Hai-Feng Yin, Zhen-Sheng Wang, Jian-He Xu,