| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346728 | Tetrahedron: Asymmetry | 2015 | 4 Pages |
Abstract
Enantioselective aldol reactions of isatins with acetone using phthalimido-prolinamide organocatalyst 1 are described. The protocol was effective under solvent free and additive free reaction conditions with 20 mol % of 1 leading to the desired aldol products in good yields and with good enantioselectivities.
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(S)-3-Hydroxy-3-(2-oxopropyl)indolin-2-oneC11H11NO3[α]D20 = −24.1 (c 1, CH3OH)Source of chirality: asymmetric aldol reactionAbsolute configuration: (S)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Togapur Pavan Kumar, Nemali Manjula, Kumar Katragunta,