| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346768 | Tetrahedron: Asymmetry | 2010 | 4 Pages |
Abstract
The rhodium-catalyzed asymmetric hydrogenation of 2-substituted N-protected-indoles using monodentate phosphoramidites as ligands was examined. Full conversion and 74% ee, were obtained with a catalyst based on PipPhos. The use of a catalytic amount of base is necessary for activity; best results were obtained with Cs2CO3.
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Methyl (S)-1-acetyl-2,3-dihydro-1H-indole-2-carboxylateC12H13NO3Ee 74%[α]D = −43.8 (c 1.03, CHCl3)Absolute configuration: (S)Source of chirality: catalytic asymmetric hydrogenation
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Nataša Mršić, Thomas Jerphagnon, Adriaan J. Minnaard, Ben L. Feringa, Johannes G. de Vries,