Dynamic resolution of α-halo carboxylic acid derivatives in asymmetric nucleophilic substitution using chiral auxiliaries

Recent results on the chiral auxiliary-mediated dynamic resolution of α-halo acid derivatives in nucleophilic substitution have been outlined and classified into two major mechanistic categories, dynamic thermodynamic resolution (DTR) and dynamic kinetic resolution (DKR). Asymmetric nucleophilic substitution of α-halo acid derivatives with various nitrogen, oxygen, sulfur, and carbon nucleophiles is widely used for the stereoselective preparation of α-substituted carboxylic acids.

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