| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346868 | Tetrahedron: Asymmetry | 2009 | 5 Pages |
Abstract
The use of recombinant carbonyl reductase biocatalysts for the reduction of alpha-halo ketone intermediates to their corresponding alpha-halo alcohols has been investigated. The alpha-halo alcohol is obtained in good yield from the corresponding ketone in a stereoselective manner.
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((1S,2R)-1-Benzyl-3-chloro-2-hydroxy-propyl)-carbamic acid tert-butyl esterC15H22ClNO3De = 100%[α]D20=-40 (c 0.1, CHCl3)Source of chirality: asymmetric bioreductionAbsolute configuration: (1S,2R)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Emmanuelle Alanvert, Claire Doherty, Thomas S. Moody, Nicholena Nesbit, Andrew S. Rowan, Stephen J.C. Taylor, Fatima Vaughan, Tony Vaughan, Jonathan Wiffen, Ian Wilson,