| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1346972 | Tetrahedron: Asymmetry | 2009 | 4 Pages |
Abstract
Microorganisms were used to reduce ethyl 4-chloroacetoacetate (CAAE) to ethyl (S)-4-chloro-3-hydroxybutanoate [(S)-CHBE]. Mucor ramannianus provided 98% conversion with 84% ee. Free cells of Kluyveromyces marxianus led to 95% conversion with 81% ee. After a fractionary factorial design to study the reaction conditions, calcium alginate immobilized cells of K. marxianus furnished the product with 99% conversion with 91% ee.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Joyce Benzaquem Ribeiro, Aline de Souza Ramos, Sorele Batista Fiaux, Selma Gomes Ferreira Leite, Maria da Conceição Klaus V. Ramos, Francisco Radler de Aquino Neto, Octavio A.C. Antunes,