| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1347003 | Tetrahedron: Asymmetry | 2010 | 9 Pages |
Abstract
The investigation of the stereoselective reaction of α-thiopropanoyloxazolidin-2-ones with NCS to yield α-thio-β-chloropropenyloxazolidin-2-ones is described. Diastereoselective sulfur oxidation of the resulting α-thio-β-chloropropenyloxazolidin-2-ones shows modest diastereocontrol. However, via a combination of diastereoselective oxidation and subsequent kinetic resolution in the sulfoxide oxidation, diastereoselectivities of up to 94% de have been achieved.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Marie Kissane, Maureen Murphy, Simon E. Lawrence, Anita R. Maguire,