| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1347208 | Tetrahedron: Asymmetry | 2009 | 5 Pages |
The improvement of the enzymatic performance of Aspergillus terreus and Rhizopus oryzae in enantioselective bioreductions by using glycerol as a co-solvent has been studied. In the most of the bioreductions, glycerol has demonstrated its potential for improved conversions (up to >99%) and enantioselectivities (up to >99%) when compared to reactions in aqueous or other aqueous–organic media (THF, diethyl ether, toluene, DMSO and acetonitrile). Moreover, high isolated yields of the desired chiral alcohols have been obtained on a preparative scale showing the great potential of this green solvent in biocatalysis.
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C8H9ClO(S)-1-(2-Chlorophenyl)ethanol•Ee = 99%•[α]D24=-59.8 (c 1.0, CHCl3)•Absolute configuration: (S)•Source of chirality : Bioreduction
