| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1347253 | Tetrahedron: Asymmetry | 2009 | 6 Pages |
Abstract
A resin-supported N-terminal prolyl peptide having a β-turn motif and a polyleucine tether has been developed for the organocatalytic asymmetric transfer hydrogenation under aqueous conditions. Polyleucine accelerated the reaction in a highly enantioselective manner by providing a hydrophobic microenvironment around the prolyl residue. The investigation of catalyst structures indicates that the l-form of polyleucine is essential for both reaction efficiency and enantioselectivity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kengo Akagawa, Hajime Akabane, Seiji Sakamoto, Kazuaki Kudo,