| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1347410 | Tetrahedron: Asymmetry | 2009 | 4 Pages |
Abstract
An unexpected inversion of enantioselectivity, dependent on the degree of quinine loading, was observed during the desymmetrization of glutaric meso-anhydrides. Decrease in catalyst loading from 1.6 equiv to 0.1 equiv caused a clear inversion of stereochemistry—from about 40% ee of (R)-configuration to about 40% ee of the opposite enantiomer. The effect of various carboxylic acid additives was also studied.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Trpimir Ivšić, Zdenko Hameršak,