| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1347708 | Tetrahedron: Asymmetry | 2008 | 5 Pages |
Abstract
Two novel P,O-coordinating chiral phoshine-amide ligands with hydroxymethyl side chains 5a and 5b were prepared and tested in some benchmark Pd(0) catalysed asymmetric allylic alkylations. The conversions and enantioselectivities were generally good, with a highest conversion of 92% and a highest ee of 62% obtained using 1,3-diphenylpropenyl acetate as substrate. A number of palladium pre-catalysts were used, but it was [Pd(allyl)Cl]2 which gave the best results. Ligand 5b was seen to give better enantioselectivities.
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Authors
Vanda Raquel Marinho, Ana Isabel Rodrigues, Anthony J. Burke,