| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1347715 | Tetrahedron: Asymmetry | 2008 | 12 Pages |
Abstract
Lipase mediated DKR followed by a chemical and an enzymatic hydrolytic step were combined for the synthesis of enantiopure l-benzofuranyl- and l-benzothienyl alanines.
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l-2-Amino-3-(benzofuran-2-yl)propanoic acidC11H11NO3[α]D20=-14.5 (c 1, CH3COOH)Ee >99% on Chirobiotic-Tag HPLC column
l-2-Amino-3-(benzo[b]thiophen-2-yl)propanoic acidC11H11NO2S[α]D20=-23.8 (c 1, CH3COOH)Ee >99% on Chirobiotic-Tag HPLC column
l-2-Amino-3-(benzofuran-3-yl)propanoic acidC11H11NO3[α]D20=-8.0 (c 1, CH3COOH)Ee >99% on Chirobiotic-Tag HPLC column
l-2-Amino-3-(benzo[b]thiophene-3-yl)propanoic acidC11H11NO2S[α]D20=-26.0 (c 1, CH3COOH)Ee >99% on Chirobiotic-Tag HPLC column
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
![Chemoenzymatic preparation of enantiopure l-benzofuranyl- and l-benzo[b]thiophenyl alanines](/preview/png/1347715.png "First Page Preview: Chemoenzymatic preparation of enantiopure l-benzofuranyl- and l-benzo[b]thiophenyl alanines")
Authors
Paula Veronica Podea, Monica Ioana Toşa, Csaba Paizs, Florin Dan Irimie,