| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348004 | Tetrahedron: Asymmetry | 2008 | 5 Pages |
Abstract
A siloxy-l-serine organocatalyst has been developed to catalyze the asymmetric three-component Mannich reactions in the presence of water via a biphasic system, furnishing the Mannich products in good yields and high enantioselectivities.
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(2S)-2-Benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-propionic acidC19H25NO3Si[α]D23=+2.6 (c 1.94, MeOH)Source of chirality: Z-Serine-OHAbsolute configuration: (S)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Yong-Chua Teo, Jun-Jie Lau, Man-Chao Wu,