| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348076 | Tetrahedron: Asymmetry | 2008 | 21 Pages |
Abstract
Jaspine B (pachastrissamine), which was isolated in 2002, is a naturally occurring anhydrophytosphingosine which displays potent biological activity, and as such has attracted much attention from synthetic chemists in recent years, with 14 syntheses reported to date. This review delineates the isolation of jaspine B, and laboratory total syntheses of jaspine B, 2-epi-jaspine B and analogues, which serves to confirm their structure and stereochemistry.
Graphical abstractA review of the syntheses and structural assignments of jaspine B (pachastrissamine) and 2-epi-jaspine B is presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Elin Abraham, Stephen G. Davies, Paul M. Roberts, Angela J. Russell, James E. Thomson,