| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348160 | Tetrahedron: Asymmetry | 2006 | 7 Pages |
Abstract
An l-phenylalanine derived oxadiazinanone bearing an isopropyl group at the N4-position was prepared and acylated with either hydrocinnamoyl or propanoyl chloride. These oxadiazinanones were utilized in titanium-mediated asymmetric aldol reactions with aromatic and aliphatic aldehydes. The diastereoselectivities observed from these reactions ranged from fair to very good and suggested that the N4-isopropyl-l-phenylalanine based oxadiazinanones are conformationally and configurationally stable at the N4-nitrogen.
Related Topics
Physical Sciences and Engineering
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Authors
Delvis D. Dore, James R. Burgeson, Ryan A. Davis, Shawn R. Hitchcock,