Lewis-acid-mediated enantioselective silylphosphination of aldehydes: preparation of optically active α-hydroxyalkylphosphine derivatives

An enantioselective silylphosphination of aldehydes mediated by a chiral Lewis acid is described. The chiral Lewis acid prepared from TiCl4 and diisopropyl l-tartrate successfully induced chirality in the addition of silylphosphine to several aldehydes, to give the corresponding α-hydroxyalkylphosphine derivatives in good yields and good enantioselectivities.