| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348329 | Tetrahedron: Asymmetry | 2007 | 8 Pages |
Abstract
An efficient biocatalytic process has been developed for the resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate rac-1 by means of Seaprose S-mediated enantioselective hydrolysis to afford (1S)-2 and (1R)-1 in 87% and 93% isolated yield, 101% and 96% potency, and ee >99.8% and >99.5%, respectively.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Iqbal S. Gill, Ellen Kick, Kate Richlin-Zack, Wu Yang, Yufeng Wang, Ramesh N. Patel,