| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348457 | Tetrahedron: Asymmetry | 2006 | 9 Pages |
Abstract
Polymer-supported chiral amines were effectively prepared from amino acid derivatives and Merrifield resin. Treatment of polymer-supported amines with n-butyllithium gave the corresponding polymer-suppported chiral lithium amide bases, which were tested in the asymmetric deprotonation reactions of prochiral ketones. Trimethylsilyl enol ethers were obtained in up to 82% ee at room temperature. The polymer-supported chiral lithium amides can be readily recycled and reused without any significant loss of reactivity or selectivity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Lili Ma, Paul G. Williard,