| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348493 | Tetrahedron: Asymmetry | 2006 | 4 Pages |
Abstract
Asymmetric catalysis of Mukaiyama aldol addition reactions of methyl 3-TMSO-2-diazo-3-butenoate 4 with aromatic aldehydes using AgF/(R)-BINAP at −20 °C produces chiral diazoacetoacetates in high chemical yields and with high enantiocontrol.
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Methyl 5-(p-chlorophenyl)-2-diazo-5-hydroxy-3-oxopentanoateC12H11ClN2O4Ee = 92%[α]D24.3=-63.6 (c 0.506, CH2Cl2)Source of chirality: asymmetric Mukaiyama aldol additionAbsolute configuration: (S) tentatively
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kousik Kundu, Michael P. Doyle,