| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348496 | Tetrahedron: Asymmetry | 2006 | 8 Pages |
Abstract
Enantioselective C–C bond formations between the sp3 C–H bond of prochiral CH2 and terminal alkynes via the cross-dehydrogenative coupling (CDC) reaction were studied. Efficient asymmetric syntheses of alkynyl tetrahydroisoquinoline derivatives were achieved by using a catalytic amount of CuOTf together with PyBox chiral ligand. When dihydroisoquinolinium salts were used as electrophiles, the combination of CuBr/QUINAP provided the best results for asymmetric syntheses of alkynyl tetrahydroisoquinoline derivatives. The factors influencing the enantioselectivity were studied.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Zhiping Li, Patricia D. MacLeod, Chao-Jun Li,