| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348508 | Tetrahedron: Asymmetry | 2006 | 8 Pages |
Abstract
Regio- and stereoselective lipase-catalyzed kinetic resolutions were investigated for some unsymmetrical, secondary/secondary syn-diols. Candida antarctica lipase B-catalyzed transesterifications of a few aryl/alkyl- and alkyl/alkyl 1,2-diols were coupled in one-pot for efficient ruthenium-catalyzed epimerization and intramolecular acyl migration to give a dynamic kinetic asymmetric transformation (DYKAT) affording enantioenriched (ee up to >99%) syn-diacetates as the main diastereomers (syn:anti ∼2:1 to 10:1).
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Michaela Edin, Belén Martín-Matute, Jan-E. Bäckvall,