| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1348753 | Tetrahedron: Asymmetry | 2006 | 5 Pages |
Abstract
Chiral N-heterocyclic carbenes (NHC) were synthesized from naturally occurring podophyllotoxin. Their coordination with [(η3-allyl)Pd(Br)]2 afforded (NHC)Pd(allyl)Br complexes, whose structures were unambiguously established by X-ray single crystal analysis. These chiral NHC and NHC-Pd-allyl complexes were found to catalyze the substitution reaction of allylic compounds with high conversions and enantioselectivities (up to 87% ee).
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(R,E)-Diethyl 2-(1,3-diphenylallyl)malonateC22H24O4Ee = 87%[α]D25=+15.1 (c 1.40, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (R)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Shi-Jun Li, Jian-Hua Zhong, Yan-Guang Wang,