Enantioselective preparation and structural and conformational analysis of the chiral solvating agent α,α′-bis(trifluoromethyl)-1,8-anthracenedimethanol

The preparation of the enantiomers of α,α′-bis(trifluoromethyl)-1,8-anthracenedimethanol is described, and their conformational behaviour studied. These enantiomers are very active when used as chiral solvating agents in the presence of several compounds.

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(R,R)-α,α′-Bis(trifluoromethyl)-1,8-anthracenedimethanolC18H12F6O2[α]25=-8.2[α]25=-8.2 (c 2, MeOH)