| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1349100 | Tetrahedron: Asymmetry | 2006 | 5 Pages |
Abstract
Isomers of α-1′-hydroxyethyl-γ-butyrolactone can be considered as potential GHB receptor ligands designed by the molecular hybridization of GLB 2 and GHV 4. Using Aspergillus niger, Geotrichum candidum, and Kluyveromyces marxianus, it was possible to obtain (+)-(3R,1′S)-α-1′-hydroxyethyl-γ-butyrolactone in good to excellent conversions, diastereoisomeric and enantiomeric excesses. The corresponding enantiomer, (−)-(3S,1′S)-α-1′-hydroxyethyl-γ-butyrolactone was also produced in good conversion, and diastereoisomeric and enantiomeric excesses using Hansenula sp.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Joyce Benzaquem Ribeiro, Livia Maria Andrade de Sousa, Mariana da Volta Soares, Maria da Conceição Klaus V. Ramos, Francisco Radler de Aquino Neto, Carlos Alberto Mansour Fraga, Selma G. Ferreira Leite, Yraima Cordeiro, Octavio A.C. Antunes,