Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1349141 | Tetrahedron: Asymmetry | 2005 | 5 Pages |
Abstract
Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen’s catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up.
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(S)-2-Propanol, 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino}C18H29NO3Ee = >99%[α]D = −7.1 (c 1, CHCl3)Source of chirality: hydrolytic kinetic resolutionAbsolute configuration: S
(S)-Oxirane, {[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]methyl}C15H20O3Ee = >99%[α]D = +2.05 (c 1, CHCl3)Source of chirality: hydrolytic kinetic resolutionAbsolute configuration: S
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Ramesh A. Joshi, Dinesh R. Garud, M. Muthukrishnan, Rohini R. Joshi, M.K. Gurjar,