| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1349187 | Tetrahedron: Asymmetry | 2010 | 5 Pages |
Abstract
The first chiral electron-poor guanidine organocatalysts were synthesized. The presence of a tunable electron-withdrawing group on the guanidine moiety allows for the modulation of the catalysts’ activity. The application of this new class of organocatalysts to the Michael reaction is demonstrated.
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(E)-N-(((1R,2R)-2-(Dimethylamino)cyclohexylamino)(4-methoxyphenylamino)methylene)-4-methylbenzenesulfonamideC23H32N4O3SEe = 99%[α]D22=-8.2 (c 2.4, CHCl3)Source of chirality: (1R,2R)-(−)-1,2-diaminocyclohexaneAbsolute configuration: (1R,2R)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Karen Thai, Michel Gravel,