| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1349283 | Tetrahedron: Asymmetry | 2006 | 7 Pages |
Abstract
Three racemic esters based on the 1,5-diarylpyrrole structure, which proved to be highly selective COX-2 inhibitors endowed with an appreciable anti-inflammatory activity in some animal models, were subjected to chiral resolution. Their absolute configurations were assigned by comparison of the CD spectrum measured on-line with a HPLC-CD detector, with that calculated by means of a TDDFT method.
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Authors
Lorenzo Di Bari, Gennaro Pescitelli, Piero Salvadori, Michele Rovini, Maurizio Anzini, Andrea Cappelli, Salvatore Vomero,