Asymmetric synthesis of hydroxyphosphonates

Hydroxyphosphonates have attracted considerable attention as biologically active compounds, enzyme inhibitors, and drugs. Over the last few years significant interest in the asymmetric synthesis and practical application of chiral hydroxyphosphonates has been reported, which shows the theoretical interest and the practical importance of hydroxyphosphonates. An overview of recent synthetic approaches to chiral hydroxyphosphonates and determinations of their absolute configuration is presented. Data on the practical applications of hydroxyphosphonates are also discussed.

Graphical abstractAn overview of recent synthetic approaches to chiral hydroxyphosphonates and the determination of their absolute configurations is presented. Data on the practical application of hydroxyphosphonates are discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide