Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1349413 | Tetrahedron: Asymmetry | 2005 | 6 Pages |
Abstract
Using a recombinant E. coli strain overexpressing yeast reductase Ara1p, we reduced racemic 3-oxo-4-phenyl-β-lactam to cis-(3S,4R)-3-hydroxy-4-phenyl-β-lactam as a single enantiopure product. The dynamic kinetic resolution occurred over the course of fermentation at pH 7. Under the same conditions, 3-oxo-4-(2-thiophenyl)-β-lactam 4 and 3-oxo-4-(2-furyl)-β-lactam 5 were not resolved.
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Authors
Yan Yang, Melissa Drolet, Margaret M. Kayser,