Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1349506 | Tetrahedron: Asymmetry | 2006 | 6 Pages |
Abstract
Two methods are reported for synthesizing a chiral allylic alcohol from the corresponding racemic α,β-unsaturated ketone. Transition metal-based transfer hydrogenation provides the desired allylic alcohol in high enantiomeric purity but low diastereomeric excess. In contrast, an enzymatic dynamic kinetic reduction proceeds with high diastereoselectivity and enantioselectivity.
Graphical abstractTransition metal-based transfer hydrogenation provides the allylic alcohol in high enantiomeric purity but low diastereomeric excess. In contrast, an enzymatic dynamic kinetic reduction proceeds with high diastereoselectivity and enantioselectivity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Birgit Kosjek, David M. Tellers, Mirlinda Biba, Roger Farr, Jeffrey C. Moore,