The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications

This review delineates the scope and limitations of the conjugate addition of homochiral lithium amides to act as homochiral ammonia equivalents for the asymmetric synthesis of a range of β-amino carboxylic acid derivatives and its widespread applications in synthesis.

Graphical abstractThe scope, limitations and synthetic applications of homochiral lithium amides to act as homochiral ammonia equivalents in conjugate additions to α,β-unsaturated carboxylic acid derivatives are reviewed.Figure optionsDownload full-size imageDownload as PowerPoint slide