Tactics and strategies for the synthesis of iminosugar C-glycosides: a review

Three decades after their first synthesis, iminosugar C-glycosides have become an important class of iminosugars with promising biological and therapeutic properties. The purpose of this review is to provide an overview of the versatile strategies that have been developed to synthesize this family of stable imino-analogues of glycosides and glycoconjugates. Some guidelines and predictive stereoselective models are presented to facilitate the design of synthetic strategies toward iminosugar C-glycosides of defined configuration.

Graphical abstractThe purpose of this review is to provide an overview of the versatile strategies that have been developed to synthesize imino-C-glycosides as stable analogues of imino-glycosides and imino-glycoconjugates.Figure optionsDownload full-size imageDownload as PowerPoint slide