| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1350630 | Tetrahedron: Asymmetry | 2007 | 9 Pages |
Abstract
The conjugate addition of ethyl α-cyanoacetate with chalcones has been developed. In the presence of cinchona alkaloid-derived thiourea organocatalyst 1i (10 mol %), ethyl α-cyanoacetate could react with various chalcones to afford Michael adducts with high yields (80-92%) and enantioselectivities (83-95% ee).
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Chun-ling Gu, Li Liu, Yong Sui, Jun-Lin Zhao, Dong Wang, Yong-Jun Chen,