| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1350695 | Tetrahedron: Asymmetry | 2006 | 15 Pages |
Abstract
Seven chiral target molecules containing a hydroxy group have been resolved by both biocatalytic and chemical means. The lipase-catalyzed acylation mainly yielded the acylated derivative of the (R)-alcohols with moderate enantiomeric excess and the enantiopure (S)-alcohols. In the course of the chemical resolution, first the dicarboxylic acid monoesters of the target molecules were synthesized and the resolution of these monoesters was attempted by different homochiral bases. By re-resolution and/or optimization of the reaction time and/or recrystallization, respectively, each molecule was produced in very high enantiomeric purity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Violetta Kiss, Gabriella Egri, József Bálint, István Ling, József Barkóczi, Elemér Fogassy,