Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1350899 | Tetrahedron: Asymmetry | 2005 | 5 Pages |
Abstract
Deracemization of (±)-3-hydroxy-4-chromanone 2 through stereoselective bioreduction to the corresponding (3R,4S)-3,4-chromanediol 3, with good to excellent enantiomeric excesses (up to 99%), mediated by resting cells of the yeast Trichosporon cutaneum CCT 1903, is reported. In addition, 3-hydroxychromone (7) was obtained as a secondary product.
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(3R,4S)-3,4-ChromanediolC9H10O3Ee = up to 99%[α]D20=+77.5 (c 0.87, THF)Source of chirality: biocatalytic reductionAbsolute configuration: (3R,4S)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Inês Lunardi, Gelson J.A. Conceição, Paulo J.S. Moran, J. Augusto R. Rodrigues,