Flavanone derivatives from Macaranga tanarius

•A new flavanone derivative was isolated from the leaves of Macaranga tanarius.•The flavanones isolated from M. tanarius of different regions were derivatives of eriodictyol containing isoprenyl and/or geranyl side chains.•Macaranga pruinosa and Macaranga triloba have flavanone constituent(s) in common with those found in M. tanarius.

A new flavanone, epoxynymphaeol C (1), was isolated from the acetone extract of the leaves of Macaranga tanarius, together with two known compounds, nymphaeols B (2) and C (3). The structure of the new compound was determined by NMR and mass spectral data. Chemotaxonomic significance for the presence of the flavanone derivatives in M. tanarius is discussed.