| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1355105 | Bioorganic Chemistry | 2015 | 6 Pages |
Abstract
•Four isomers of fluoro-substituted benzoxaboroles: synthesis, multinuclear NMR, pKa.•Activity against several fungi.•6-Fluorobenzoxaborole: molecular and crystal structure compared with AN2690.
5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Agnieszka Adamczyk-Woźniak, Małgorzata K. Cabaj, Paulina M. Dominiak, Patrycja Gajowiec, Błażej Gierczyk, Jacek Lipok, Łukasz Popenda, Grzegorz Schroeder, Ewelina Tomecka, Piotr Urbański, Dorota Wieczorek, Andrzej Sporzyński,