Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1355371 | Bioorganic Chemistry | 2007 | 10 Pages |
Abstract
Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity.
Graphical abstractA series of Toyocamycin analogues were examined as potential anti-HCV agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chamakura V.N.S. Varaprasad, Kanda S. Ramasamy, Jean-Luc Girardet, Esmir Gunic, Vicky Lai, Weidong Zhong, Haoyun An, Zhi Hong,