Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1355611 | Bioorganic Chemistry | 2015 | 8 Pages |
•New 5′-O-glycyl and 5′-N-glycyl derivatives of uridine were synthesized.•Compound A4 showed moderate inhibition against 1,4-β-galactosyltransferase.•STD NMR study confirmed binding of compound A4 into bovine serum albumin.
New 5′-glycyl derivatives of uridine containing fragments of varying lipophilicity were synthesized as analogues of natural peptidyl antibiotics. One of the studied compounds, 5′-O-(N-succinylglycyl)-2′,3′-O-isopropylideneuridine (A4), showed moderate inhibition against 1,4-β-galactosyltransferase. However, additional studies showed that the observed inhibitory effect was due to binding to bovine serum albumin, which was used in assays as a stabilizer.
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