| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1355710 | Bioorganic Chemistry | 2016 | 8 Pages |
•A series of piperazine-benzothiazole analogues 6a–j were synthesized.•Synthesized compounds were characterized by spectral studies.•Compounds 6a–j were evaluated for in vitro anti-proliferative activity.•Compound 6c showed extensive antiproliferative activity.•Compound 6c shows increased tumor suppression through inhibition of angiogenesis.
A novel series of benzoic acid N′-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides 6a–j were synthesized and characterized by IR, 1H, 13C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a–j were evaluated against Dalton’s lymphoma ascites (DLA) cells. Our results showed that compound 6c with a bromo group on phenyl ring has showed promising antiproliferative efficacy. Further investigation of compound 6c on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis.
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