Structural determination Vitex cymosa Bertero active principle: Diastereoselective synthesis of (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one and its antinociceptive activity

The synthesis of (±)-δ-lactone 2 allowed the elucidation of the correct structure of Vitex cymosa Bertero active principle. The (±)-δ-lactone showed significant antinociceptive properties in preliminary tests using the tail flick model assay.