Effect of two simultaneous aza-Î²3-amino acid substitutions on recognition of peptide substrates by cAMP dependent protein kinase catalytic subunit

Article ID	Journal	Published Year	Pages	File Type
1355770	Bioorganic Chemistry	2011	5 Pages	PDF

Abstract

âº Peptidomimetics containing two aza-Î²3-amino acids were phosphorylated by protein kinase A. âº Effect of amino acid replacement by aza-Î²3 analogs was dependent on position of this replacement. âº Influence of two aza-Î²3-amino acids was bigger than sum of effects caused by single replacements. âº Substrate backbone specificity clusters can be defined by using peptidomimetics.

Keywords

Peptidomimetics BSA bovine serum albumin Phosphorylation HATU protein kinase A cAMP-dependent protein kinase